diff --git a/misc/py-numcodecs/Makefile b/misc/py-numcodecs/Makefile
index e947fcb1bd86..7399a72df1ab 100644
--- a/misc/py-numcodecs/Makefile
+++ b/misc/py-numcodecs/Makefile
@@ -1,13 +1,13 @@
 PORTNAME=	numcodecs
-DISTVERSION=	0.13.0
-PORTREVISION=	1
+DISTVERSION=	0.16.1
 CATEGORIES=	misc python
 MASTER_SITES=	PYPI
 PKGNAMEPREFIX=	${PYTHON_PKGNAMEPREFIX}
 
 MAINTAINER=	yuri@FreeBSD.org
 COMMENT=	Package providing buffer compression and transformation codecs for use
-WWW=		https://numcodecs.readthedocs.io/en/stable/
+WWW=		https://numcodecs.readthedocs.io/en/stable/ \
+		https://github.com/zarr-developers/numcodecs
 
 LICENSE=	MIT
 LICENSE_FILE=	${WRKSRC}/LICENSE.txt
@@ -20,18 +20,22 @@ RUN_DEPENDS+=	${PYTHON_PKGNAMEPREFIX}msgpack>0:devel/py-msgpack@${PY_FLAVOR} \
 		${PYTHON_PKGNAMEPREFIX}zfp>0:devel/py-zfp@${PY_FLAVOR}
 
 USES=		python
-USE_PYTHON=	distutils cython autoplist pytest # tests fail to find the library in the staged directory for some reason
+USE_PYTHON=	distutils cython3 autoplist pytest # tests fail to find the library in the staged directory for some reason
 
 CXXFLAGS_i386=	-msse2 # otherwise it fails to compile: #error SSE2 is not supported by the target architecture/platform and/or this compiler.
 
 TEST_ENV=	${MAKE_ENV} PYTHONPATH=${STAGEDIR}${PYTHONPREFIX_SITELIBDIR}
 TEST_WRKSRC=	${WRKSRC}/numcodecs/tests
 
-OPTIONS_DEFINE=		AVX2
-
+OPTIONS_DEFINE=		AVX2 CRC32C PCODEC
 AVX2_DESC=		Use AVX2 SIMD instructions
+CRC32C_DESC=		Use crc32c algorithm
+PCODEC_DESC=		Use compression via pcodec
+
 AVX2_CONFIGURE_ENV_OFF=	DISABLE_NUMCODECS_AVX2=yes
 AVX2_MAKE_ENV_OFF=	DISABLE_NUMCODECS_AVX2=yes
+CRC32C_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}crc32c>=2.7:devel/py-crc32c@${PY_FLAVOR}
+PCODEC_RUN_DEPENDS=	${PYTHON_PKGNAMEPREFIX}pcodec>=0.3<0.4:math/py-pcodec@${PY_FLAVOR}
 
 .include <bsd.port.options.mk>
 
@@ -40,6 +44,6 @@ MAKE_ENV+=	DISABLE_NUMCODECS_SSE2=yes DISABLE_NUMCODECS_AVX2=yes
 .endif
 
 post-install:
-	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/numcodecs/*${PYTHON_TAG}.so
+	@${STRIP_CMD} ${STAGEDIR}${PYTHON_SITELIBDIR}/numcodecs/*.so
 
 .include <bsd.port.mk>
diff --git a/misc/py-numcodecs/distinfo b/misc/py-numcodecs/distinfo
index 263ad8d5532a..9377f52553e6 100644
--- a/misc/py-numcodecs/distinfo
+++ b/misc/py-numcodecs/distinfo
@@ -1,3 +1,3 @@
-TIMESTAMP = 1720850082
-SHA256 (numcodecs-0.13.0.tar.gz) = ba4fac7036ea5a078c7afe1d4dffeb9685080d42f19c9c16b12dad866703aa2e
-SIZE (numcodecs-0.13.0.tar.gz) = 5922216
+TIMESTAMP = 1748849887
+SHA256 (numcodecs-0.16.1.tar.gz) = c47f20d656454568c6b4697ce02081e6bbb512f198738c6a56fafe8029c97fb1
+SIZE (numcodecs-0.16.1.tar.gz) = 6268134
diff --git a/misc/py-numcodecs/files/patch-pyproject.toml b/misc/py-numcodecs/files/patch-pyproject.toml
new file mode 100644
index 000000000000..605701f1fee0
--- /dev/null
+++ b/misc/py-numcodecs/files/patch-pyproject.toml
@@ -0,0 +1,16 @@
+--- pyproject.toml.orig	2025-05-22 13:25:07 UTC
++++ pyproject.toml
+@@ -33,12 +33,7 @@ maintainers = [
+ maintainers = [
+     { name = "Alistair Miles", email = "alimanfoo@googlemail.com" },
+ ]
+-license = "MIT"
+-license-files = [
+-    "LICENSE.txt",
+-    "c-blosc/LICENSE.txt",
+-    "c-blosc/LICENSES/*",
+-]
++license = { text = "MIT" }
+ 
+ [project.urls]
+ "Bug Tracker" = "https://github.com/zarr-developers/numcodecs/issues"